Dan posted in another thread that there was a major server problem yesterday, but that seems to be fixed now. Is it still affecting you?

Yes, issue is still there.

Dan suggested stacking artifacts to see if it helps. I do that regularly but I did it again and checked to see if there was any improvement. It did help some - but the issue is still very much there.

I noticed that stacking artifacts helped reduce delay more with mission clicks than NPC or player fights. Could be wrong, delays being very random (I could get 3-4 clicks in a row then completely hang for over a minute), but that's how it seemed to me.

After long delays, I sometimes lose all data on screen - its just empty frames with menus.

Update : issue is still there.

I tried using again Google Chrome this morning. For the small amount of time I've used it so far, it was much much faster. When I tried a few weeks ago, it didn't help, but now it seems so. Gonna try it a few days and see if it stays fast.